Rap1 is a close relative of the small GTPase Ras, and was identified in a screen for revertants of cells oncogenically transformed by mutant Ras. Rap1 is activated — that is increased GTP-bound over ...

Chronic activation of the Ras-like (Ral) guanyl nucleotide-binding proteins, RALA and RALB, occurs in tumour-derived cell lines and tumour samples. Depletion of RALA severely impairs the ...