CRISPR-Cas系统是细菌抵御病毒入侵的关键适应性免疫机制，而噬菌体等可移动遗传元件则进化出多种“反CRISPR”蛋白来对抗这一防御。研究发现，噬菌体可利用一类特殊的RNA分子来干扰CRISPR-Cas系统（RacrIF1）。然而，RacrIF1 ...

原核生物与移动遗传元件（MGEs）如噬菌体、质粒和转座子之间存在着持续不断的进化军备竞赛。这种竞争不仅驱动了多样化和复杂的抗病毒防御系统的进化，而且导致病毒也相应地发展出多种反防御策略。CRISPR-Cas ...

(a) Utilizing HCR and CRISPR-Cas12a double amplification technique, a highly sensitive apta-HCR-CRISPR method was devised for the detection of TEV protein. (b) A novel CRISPR-Cas12a/Cas13a approach, ...

The CRISPR/Cas system, known for gene editing, is now revolutionizing molecular diagnostics due to its high specificity and efficiency in recognizing and cleaving target sequences. Cas9, Cas12, and ...

细菌与噬菌体之间的军备竞赛已经持续了数十亿年。这场没有硝烟的战争催生了地球上最复杂、最精巧的防御系统。当我们以为自己已经通过Cas9、Cas12a或Cas13窥探到了CRISPR-Cas系统的全貌时，自然界总能以一种令人惊叹的方式提醒我们：我们所知的，不过是冰山一角。

Cas proteins conduct adaptive immunity in prokaryotes (bacteria) based on immunological memories stored in the CRISPR array. The CRISPR/Cas system integrates a small piece of foreign DNA from invaders ...

Scientists have revealed how Fanzor2's divergence from bacterial ancestors may make it a useful tool for future genomic engineering endeavors. A revolution in biomedicine is currently underway, driven ...

Researchers have discovered a handful of new CRISPR-Cas systems that could add to the capabilities of the already transformational gene editing and DNA manipulation toolbox. Of the new recruits, one ...

Genetic disorders occur due to alterations in the primary genetic material—deoxyribonucleic acid (DNA)—of an organism. Transthyretin amyloidosis (ATTR) is a progressive disorder involving amyloid ...

The clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated proteins (Cas) system is a bacterial defense mechanism that uses RNA-guided enzymes to cut specific sequences ...